By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.

Author: Gotilar Shaktirn
Country: French Guiana
Language: English (Spanish)
Genre: Travel
Published (Last): 24 April 2018
Pages: 362
PDF File Size: 9.89 Mb
ePub File Size: 20.39 Mb
ISBN: 664-2-86549-868-8
Downloads: 13089
Price: Free* [*Free Regsitration Required]
Uploader: JoJozragore

The purpose of this article is to describe about the liqjisolid technique like basics, classification, preformulation studies, characterisation, precompression studies, formulation of tablet, postcompression studies, advantages, disadvantages, applications. The drug content is analyzed using UV-Visible spectrophotometer. Dissolution rate enhancement of fenofibrate using liquisolid tablet technique. When drug dissolved in liquid carrier is poured onto a porous carrier material, liquid gets absorbed in its internal structure, and after saturation, adsorption on external surface occurs.

Preformulation studies Formulation of liquisolid compacts.


The Liquisolid compacts have two major formulation components namely, powder substrate and liquid medication. United State Patent, ;However, depending on the sorbent properties, both of these processes can occur simultaneously, and is termed sorption. In the third step suitable superdisintegrants like sodium starch Glycolate or Crosspovidone is added in the prepared mixture with continuous shaking in technque mortar.

Krishna sanka et al.

Pharmaceutical applications of liquisolid technique

Effect of powder substrate on the dissolution properties of methyclothiazide liquisolid compacts. Where, M is the total amount of pure drug in each tablet and D is the percentage of drug dissolved in the first 10 minutes Spireas et al. Studies by Javadzadeh Y.

  A7V 102 PDF

In addition, flowability studies are also to liqquisolid carried out to select the optimal formulae for compression, prior to the compression of the powders the dosage forms such as into tablets and capsules.

By adding PVP to liquid medication, it would be possible to produce dry powder formulations containing liquid with a high concentration of drug. It is first described by Spires. Liquid load factor L f: In general amorphous are more soluble than metastable polymorphs, anhydrates are more soluble than hydrates and solvates are more soluble than non-solvates.

All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. The concept behind this approach is adsorption and absorption both.

These samples are then analyzed by using infra red spectrophotometer or differential scanning Calorimetry. At near critical temperature, SCFs are highly compressible allowing moderate changes in pressure to greatly alter the density techniqje mass transport characteristics of a fluid that determines its solvent power. The poor dissolution characteristics of water insoluble drugs are a major challenge for pharmaceutical science.

Liquisolid technique has been classified on the basis of liquid active moieties, viz. The compressibility index has been proposed as an indirect measure of bulk density, size and shape, surface area, moisture content and cohesiveness liquieolid material because all of these ca influence the compressibility index.

Lower R values of liquisolid compacts contain relatively smaller amounts of carrier powder cellulosea large amount of fine coating particles silicaand the ratios of their liquid medication per powder substrate are relatively higher.

Tiong N et al. Journal of Drug Techniique and Therapeutics3 4 Liquisolid tablet contact angle is less than that of direct compressed tablets. Deagglomeration behavior of relatively insoluble benzoic acid and its sodium salt. Physicochemical properties of selected powdered drug solutions. Several methods are studied for increasing dissolution performance and bioavailability including micronization, Nanonisation, complexation with cyclodextrins, solid dispersion, self emulsifying system, liquisolid systems etc.


For the characterization of crystalline state, X-ray diffraction XRD patterns are determined for physical mixture of drug and excipients used in formulation and for the prepared liquisolid compacts. Nevertheless, best approaches are available to prepare the liquid oily medications and drug solutions of water insoluble solid drugs.

The loose bulk density and tapped density were determined by using bulk density apparatus apparent bulk density was determined by pouring the blend into a graduated cylinder.

Surfactants are very useful as absorption enhancers and enhance both dissolution rate as well as permeability of drug. Improvement of dissolution properties of carbamazepine through application of the liquisolid tablet technique.

Therefore, it is impossible with conventional tablet methods to convert high dose to liquisolid tablets with a tablet weight of less than50 mg. Classification of liquisolid techniques: Several studies have been carried out to increase the dissolution rate of drugs by decreasing the particle size, by creating nanoparticles and microparticles. Dissolution profile enhancement occurs in the presence of low levels of hydrophilic carrier, where coating material is not significant.

The results showed that liquisolid formulations exhibited significantly higher drug dissolution rates at pH 1. Can be used in controlled drug delivery.