Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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Jpn J Med ; Turn recording back on. Additional named growth factors include human-growth-hormone, transforming growth factor-alpha, and insulin-like growth factor.

Various subtypes of seborrheic keratoses exist including acanthotic most common varianthyperkeratotic, reticulated, clonal and melanoacanthoma. Get free access to newly published articles. In addition, symptomatic lesions may be destroyed with various physical methods including cryotherapy, curettage, shave removal, and electrodesiccation. The primary aim of treatment is to treat the underlying cancer. Aldrich-Mees’ lines Beau’s lines Muehrcke’s lines Terry’s nails.

Bernett ; George J. Trellat examination will typically reveal numerous seborrheic keratoses usually in a symmetric pattern on the back that may resemble a “Christmas tree,” “splash,” or “raindrop” pattern.


DermNet NZ does not provide an online consultation service. Patients will often complain of pruritus associated with these lesions. Article by Robert A Schwartz”. CA Cancer J Clin ; The criteria are as follows: Support Center Support Center.

Eruptive seborrheic keratoses associated with erythrodermic pityriasis rubra pilaris. They appear as brown warty nodules with a stuck-on appearance. Malignant involvement of the skin and the genodermatoses.

Sign of Leser-Trélat | DermNet NZ

Lesions tend to resolve once the underlying cancer is treated. Multiple eruptive seborrheic keratoses on the a face and neck, b breast, and c back Click here to view. Questions To access free multiple choice questions on this topic, click here. The Oxford illustrated companion to medicine. Leser-Trelat sign with primary hepatic carcinoma.

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On physical examination, multiple, 2- to 6-mm, seborrheic keratoses and numerous pigmented filariform papillomas were present on the dign and malar regions Figure.


Retrieved 15 July The criteria are as follows:. CA Cancer J Clin. Get free access to newly published articles Create a personal account or sign in to: Affilations 1 Orange Park.

There is a strong statistical association of the paraneoplastic process with truly having an underlying malignancy.

Leser Sigh Sign – StatPearls. Cutaneous manifestations of internal malignancies: Dermatologic signs Paraneoplastic syndromes. Sign in to access your subscriptions Sign in to your personal account. Epub Jan Published by Wolters Kluwer – Medknow.

Malignant Neoplasms and the Leser-Trélat Sign

Poole S, Fenske NA. Purchase access Subscribe now. National Center for Biotechnology InformationU.

The sign of Leser-Trelat is considered to be a fairly rare paraneoplastic cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses. Leser-Trelat sign with primary hepatic carcinoma.

Am J Med ; Andrews’ diseases of the skin: