Etude épidémiologique de la bronchite chronique dans une population agée de 60 à 85 ans. Contributions à l’étude de l’histoire naturelle de la. Les signes propres de la bronchite chronique distale et de l’emphysème au cours des syndromes de bronchopneumopathie dyspnéisante. Download Citation on ResearchGate | Physiopathologie de la toux | Cough is initiated from organs innervated by the vagus nerve. The larynx and the lower.

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BPCO Les broncho-pneumopathies chroniques obstructives.

Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique (Ile-de-France)

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease – GOLD executive summary. Blue bloater ; Pink puffer ; cyanose ; hippocratisme digital ; distension ; mode ventilatoire ; tirage ; muscles respiratoires accessoires. The recent progress in the understanding of mechanisms at the origin of this disease underlines the role of extrapulmonary cells, such as circulating stem cells and bone marrow-derived progenitor cells in vascular remodeling and in PAH development.

These chfonique aimed to clarify and better understand the abnormal phenotype of the pulmonary endothelial cell P-EC of PAH patients to identify new therapeutic targets to correct and restore the endothelial dysfunction associated with pulmonary hypertension.

Smoking characteristics – Differences in attitudes and dependance between healthy smokers and smokers with COPD.

The immunopathogenesis of chronic obstructive pulmonary disease. We found that pulmonary vascular cells express the main features of a functional synaptic-like glutamatergic communication through NMDARs. Several molecular abnormalities are the cause of these functional disturbances including production and abnormal release of ICAM-1 and FGF The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in Broncuite, and not to disclose this data to third parties.

In a first experimental study, we showed from a porcine model of chronic pulmonary hypertension that usual non-invasive indices of right ventricular function are rather associated with ventricular-arterial coupling than with contractility.


Similarly, tyrosine kinase inhibitors have shown efficacy in PAH management but associated with severe adverse events as cardiac toxicity. New knowledge in the PAH management were performed in the last few years, specifically for vasodilators. Action plans for chronic obstructive pulmonary disease. Chroniqus early recognition and treatment important? The last project described the validation of a new PAH model by a hemodynamic, histological, vascular, molecular and electrophysiological characterization of heterozygous rat mutated to Bmpr2 gene.

Alteration of ABCA1 expression predicted during bioinformatics study has been validated in human and in monocrotaline rat model.

BPCO – Bronchite Chronique – – Documentation sur les BPCO

However, only few data exist at the early stage of right ventricular dysfunction. Project Page Feedback Known Problems. Duprat-Lomon bN. This work could help to develop new therapies allowing more specific and more effective treatments leading to improved survival of PAH patients. N Eng J Med ; Proc Am Thorac Soc ;4: It is also present in cbronique cells, including aortic and cerebral vascular cells, and promotes their proliferation.

We also oberved experimentally in rats that structural and functional remodeling of the pressure overloaded right ventricle is associated withmacrophagic infiltration in the myocardium.

The first aim of this thesis was to study the association between microvascularisation impairment and right ventricular adaptation to chronic pressure overload. The disruption of cellular interactions and the activation of specific signalling pathways contribute to the development and progression of the structural changes in small pulmonary arteries.

Moreover, environmental and genetic factors may predispose to this vascular disease. Implications of reversibility testing on prevalence and risk factors for chronic obstructive pulmonary disease – a community study.

Une prise en charge effective. The balance between the supply and the increased need in oxygen is crucial to maintain an adapted right ventricular function. A better understanding of the role of endothelial dysfunction in PAH immune system dysregulation may help to the development of new therapeutical strategies for this disease.


We identified clusters of probes that discriminates controls and PAH patients. However, an impairment of the myocardial microvascularisation chornique lead to myocardial ischemia and could participate to the transition between adapted and non-adapted right ventricular hypertrophy.

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In this study, we showed that enlargement of the RV and of the right atrium, as well as function parameters of the RV were associated with PH.

As mitochondrion are involved in the entire oxygen-dependent energy production in cardiomyocytes, their integrity is also essential vhronique a good right ventricular function. La BPCO appartient au champ des maladies broncho-pulmonaires obstructives. Facteurs de risque connus. Taking together, these results showed that microvascular impairment and broncihte dysfunction had an important role in the early right ventricular dysfunction.

Pathological and proteins chdonique analyzes of the RV around 3 hours after hemodynamic restauration showed acute subendocardial and subepicardial focal ischemic lesions as well as signs of autophagy activation.

The RV was evaluated with parameters derived from pressure-volume loops, echocardiography, right heart catheterism and with circulating biomarkers.

In a large animal model with progressive increase in physiopathologiie artery mechanical obstruction, enlargement of the RV was the earliest RV parameter associated with PH development. Therefore, we analyzed the role of endothelial dysfunction in the control of two types of altered immune responses: The aim of this thesis was to evaluate non-invasive screening of PH with echocardiography and to study the pathophysiology of acute right heart failure in the setting of chronic PH by performing precise phenotyping of a new large animal model.

In the third part of this work, we studied the mitochondrial respiratory capacities in the setting of right ventricular remodeling under chronic pressure overload.